How to deal with the 'broken bottle' of cosmetic bottles during freeze-drying

In the previous article, we talked about the 'broken bottle' of cosmetic freeze-dried bottles, and we continue to talk about how to deal with cosmetic bottle freeze-drying
in
Broken bottle phenomenon.


The key to solving the problem of cosmetic bottle fragmentation and peeling during freeze-drying is to reduce the temperature difference of each part of the cosmetic bottle. The freeze-drying process curve reflects the reduction of the temperature line between the shelf temperature curve and the sample temperature curve. Interval, which can be achieved by vacuum control and temperature control in actual operation.


We first pre-cool the sample to the degree Celsius below the eutectic point, and keep the temperature for hours. When the condenser temperature reaches below minus degrees Celsius, the entire system is evacuated. After reaching the predetermined value, the temperature rise and drying will begin. At this time, the shelf temperature is set higher than the sample degrees Celsius. At the same time, the main butterfly valve is adjusted to increase the steam pressure in the drying chamber. Strengthen the effect of convection heat transfer to speed up the heat transfer process and promote the temperature of the sample to increase with the temperature of the shelf. When the pressure rises, pay close attention to the changes in air pressure and temperature to ensure that the temperature difference between the sample and the shelf is at
~
Within the range of degrees Celsius. At this time, the temperature curve of the sample is as fast as possible to approach the eutectic point, and it sublimates rapidly at about degrees Celsius below the eutectic point to complete the main drying.


After the main drying of the preparation is basically completed, the temperature can be quickly heated to make the shelf temperature directly reach the set value. Since the moisture in the cosmetic bottle has basically been sublimated, the factors that affect the temperature change no longer exist. Even if the temperature difference is greater than degrees Celsius, the glass bottle will not be broken. After the shelf temperature curve and the sample temperature curve overlap, the insulation and drying will be carried out. Complete the whole process of freeze-drying.


Through more than a year of freeze-drying work practice, using the above method to adjust the temperature, this not only shortens the freeze-drying cycle, but also solves the problem of cosmetic bottle chipping and peeling during the freeze-drying process. After comparison, we now use the improved freeze-drying process to produce cosmetic bottles that have successfully controlled the bottle breaking rate within a relatively ideal range. I believe this indicator can still be done well. The damage of each cosmetic bottle means a substantial reduction in profits. I hope this article can bring some useful thinking to the relevant pharmaceutical companies.