Preservatives are often the last thing on formulators' minds when designing a recipe, but they are the first thing on their minds when something goes wrong. An essential ingredient, it is barely felt and is valued only if it works and worthless if it doesn't. Preservatives are often criticized and misunderstood in the cosmetics industry, and because of this, people often add too much, too little or for some reason choose the wrong preservative system in the formulation system.
Just like any other type of ingredient, there are many other factors to consider when choosing a preservative for your formulation, such as the other components in the formulation, pH value, type of packaging, and country and company regulations under which the product is marketed. Other Components Most cosmetic ingredients have the ability to enhance or inhibit the activity of preservatives. The most common is that no preservatives are needed if the formula contains more than 15% ethanol. Similarly, zinc oxide, which is found in sunscreens and formulations for diapers, has anti-microbial properties of its own in cosmetic packaging. A high diol content in the formulation can enhance the effectiveness of preservatives and even control the environment for microbial survival by combining with free water, thus eliminating the need to add other preservatives. In any case, the claimed ability to reduce water content to achieve preservative effect is more of an opportunistic business, which must be confirmed by testing methods.
There are a number of issues in the cosmetic industry that would make cosmetic packaging manufacturers discuss together, such as whether products containing water, silicone oil, or no water need to be antiseptic. Those microbes caused formulers to be concerned about the presence of water in their formulations, and even though moisture may remain on the surface of the product, this is enough to cause microbial contamination. Although oil-in-water and silicon-in-water systems also contain water, some of these systems have inherent characteristics that make it difficult for microorganisms to combine with the water. This raises some intriguing questions about whether microbes from outside the product were brought in during actual use and contaminated. It is not of great reference value because the general challenge experiment causes demulsification. But it is important to identify potential contamination risks and take appropriate anti-corrosion measures. Schumer's Koko Test can be used to predict the likelihood of microbial survival in a system. In the test, the introduction of water from the inoculation suspension changed the system to some extent. In consumer use tests, more accurate results can be obtained by returning the used product to the laboratory for a plate bacterial count. While ingredients can sometimes enhance the efficacy of preservatives, they can also deactivate them. Now there are quite a few emulsion formulations are non-ionic system, it should be noted that non-ionic and high ethoxy substances will affect the activity of Nipagin esters. However, Euxyl(K 600, Euxyl(K 700 and Euxyl(K 702) are more suitable for this system. Sulfites, on the other hand, affect the activities of isothiazolinone and methyldibromoglutaronitrile (Euxyl(K 100, Euxyl(K 400 and Euxyl(K 727)). Sulfites may not be used frequently in the United States, but Cosmetic container supplier must understand that when you design a shampoo recipe in Europe, sulfites are often used as a decolorizing agent for the surfactant. In this case, Euxyl(K 300, Euxyl(K 700, and Euxyl(K 702) are good choices. It is also important for Cosmetic Container Factory to note that a suitable pH range is an important factor for the preservative to function.
The pH activity can vary greatly with a slight change in pH, such as Nipagins, benzoic acids, and dehydroacetic acids. Although we usually add them in the form of their salts, they also work only in acidic environments. When we think about these preservatives, it's important to note that the pH of the formulation that is too far from the pKa value of the acid in it will also cause it to be converted to salt and deactivated. The activity of Nipagins in systems can be improved primarily by lowering the pH of the system, typically 7.0 to 6.5 or lower, although sometimes they can maintain their efficacy in systems with slightly higher pH values. The best range is 6.5 or lower for Euxyl(K 300), 5.0 or lower for Euxyl(K 700), and 5.5 or lower for Euxyl(K 702). This allows for maximum effectiveness with the least amount of preservatives. It is also possible to avoid the instability of phenoxyethanol at certain high pH conditions.
In general, the less likely the user is to come into contact with the product in the jar, the less likely the product will be contaminated and the less preservatives will need to be added. Using cosmetic jars for lotion packaging makes it easier for users to draw dust from their fingers into the product, and keeping the product in a warm, damp bathroom provides an ideal breeding ground for a host of microbes. Pump, Cosmetic tube and disposable packaging are better to prevent the user from contaminating the product. The anti-corrosion of a product is not only related to the way users touch the product, but also the packaging materials themselves will affect the anti-corrosion system. Some cosmetic plastic containers can absorb preservative activity (e.g., Nipagins). It is therefore important that products are tested in their final packaging to ensure adequate corrosion resistance.
The country where the product is finally sold
At present, cosmetics regulations have not been unified globally. In Europe, the EU's Cosmetics Regulation Annex VI specifies the use of preservatives. This list is very broad, and also covers preservatives used elsewhere. The maximum concentration specified in Annex VI is different from that specified in the United States, Cosmetic Vinaigrette Review and Japan's Minisry of Health and Welfare. Such as: Annex VI limits all use of isothiazolinone to 15ppm, while CIR specifies a maximum of 15ppm for rinsing products and 7.5 PPM for retention products (Euxyl(K 100 for example, up to 0.2% for rinsing products). Up to 0.1% in products of residence). In Japan, isothiazolinone can only be used in rinse products. From a legislative point of view, the most stringent regulations on cosmetic preservatives are still in Japan. While restrictions on other cosmetic ingredients have been reduced over the past few years, restrictions on preservatives have not changed at all. Some "formaldehyde release agents" are still technically available, but the suggestive labels are enough to make people cringe and think twice before they act. What's left is mainly phenoxyethanol, organic acids (including Nipagins) and isothiazolinone, which is used to rinse the product. The antisepsis systems that Sumet has approved in Japan for use in final marketed products are Euxyl(K 100, Euxyl(K 300 and Euxyl(K 700 and Sensiva(SC 50), which are listed as a moisturizer in Japan.
In addition to regulatory constraints, many countries are mindful of the public debate that is unfavourable to many preservatives. Germany and Scandinavia (the generic name for Sweden, Norway, Denmark and Iceland) do not like the use of isothiazolinone preservatives. France is more concerned with phenoxyethanol. There has been a lot of talk about the impact of these ingredients, and now there is a global focus on the possibility that Nipagins may endanger estrogen. One might expect that the longer the alkyl chain of the Nipagins, the greater the effect on estrogen might be. Most European products do not use formaldehyde emitting preservatives, and Bronopol is widely used in the United Kingdom (Euxyl(K 446, Euxyl(K 145)), but the opposite is true in the United States. Because it has the potential to form nitrosites under very special conditions. In Europe, methyldibromoppenitrile can only be used later in rinsed products, but in the United States it can be used in rinsed products as well as in wash-free products. More recently, one of these European regulations has identified benzyl alcohol as an allergen to the presence of flavors, which may also raise questions about its use as a preservative. Company Regulations Many companies have detailed regulations about which preservatives can be used in their products. Some companies like to use the same preservative in all their formulations to save on input costs, as well as to mitigate the cost of raw material pricing associated with the use of different preservative monomers, but this is dangerous from an preservative standpoint. In addition to the formulation considerations described above, the use of the same preservatives in all products will naturally lead to the development of microbial resistance during production.
The easiest way to prevent microbial resistance is to use different preservatives in different types of products. A company's consideration for the use of preservatives must be taken into account in the design of the formulation, and the most important thing for different formulations is how to preserve preservatives adequately. If a formulation using a company-specified corrosion protection system fails to provide adequate and safe corrosion protection, the regulations should allow for an alternative system under very special conditions. Cosmetic formulas need to be balanced. Embalming systems should be considered at the beginning of the development of new formulations, not as an afterthought. Selecting the best preservative system for your recipe is not a difficult task. Don't stick with a preservative system just because you're used to it. It is logical and scientific to choose a preservative, which should be taken into consideration: * What other ingredients will you use? * What will the pH be? * What kind of packaging will you choose?
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