How to choose cosmetic glass bottles correctly?
Various products and different materials form a standardized system that is intertwined vertically and horizontally, which provides sufficient basis and conditions for the selection of scientific, reasonable and suitable glass containers for various drugs. The selection and application of various types of drugs of different dosage forms, properties and grades to cosmetic glass bottles should follow the following principles:
Good and suitable chemical stability principle
The glass containers used to contain various types of medicines should have good compatibility with the medicines, that is, to ensure that the chemical properties of the glass containers cannot be unstable during the production, storage and use of the medicines. The chemical reaction of these substances leads to the mutation or failure of the medicine. For example, borosilicate glass glass containers should be selected for blood preparation drugs, and borosilicate glass glass containers should be used for all kinds of strong acid and alkali water injection preparations, especially strong alkali water injection preparations. Low borosilicate glass ampoules, which are widely used in China, are not suitable for containing water injection preparations. The material of this type of glass must be gradually changed to glass material to meet my country's standards as soon as possible to ensure that the medicines contained therein will not fall off during use , No turbidity, no deterioration.
For general powder injections, oral preparations and large infusions, the use of low borosilicate glass or neutralized soda lime glass can still meet the chemical stability requirements. The degree of corrosion of drugs on glass is generally that the liquid is greater than the solid, and the alkalinity is greater than the acidity. In particular, the strong alkali aqueous injection has higher requirements for the chemical properties of cosmetic glass bottles.
Good and suitable resistance to rapid temperature change
Different dosage forms of medicines must undergo high-temperature drying, disinfection or low-temperature freeze-drying processes during production, which requires glass containers to have good and appropriate resistance to temperature changes without bursting. The resistance to rapid temperature change of glass is mainly related to the coefficient of thermal expansion. The lower the coefficient of thermal expansion, the stronger its ability to resist temperature changes. For example, many biological preparations and freeze-dried preparations should generally be selected. Borosilicate glass or. Borosilicate glass. Low borosilicate glass produced in large quantities in China is prone to explosion and bottle bottoming when subjected to large temperature differences and drastic changes. Borosilicate glass in China has developed a lot. This kind of glass is especially suitable for freeze-dried preparations because its resistance to rapid temperature changes is better than that of borosilicate glass.
Good and suitable mechanical strength
Different dosage forms of medicines need to withstand mechanical shock resistance during the production process and transportation, loading and unloading. In addition to the mechanical strength of cosmetic glass bottle containers, the mechanical strength of the glass bottle is related to the bottle shape, geometric size, and thermal processing. The glass material also has its mechanical strength. Influence, the mechanical strength of borosilicate glass is better than soda lime glass.
The issuance and implementation of the new standard for cosmetic glass bottles is important for establishing a complete and scientific standardization system, accelerating the pace of integration with my country’s standards and local markets, and for improving the quality of pharmaceutical packaging materials, ensuring the quality of pharmaceuticals, development and local trade. Will play a positive role in promoting. Of course, like the entire pharmaceutical packaging material standard system, the cosmetic glass bottle standard system that has been initially formed still has many problems that need to be further improved, improved and perfected, especially to adapt to the rapid development of the pharmaceutical industry and to meet the requirements of my country’s market integration. . In the preparation of standards, content and indicators, and the extent to which my country's standards are adopted, and the extent to which they are in line with the local markets, appropriate adjustments and supplements are required in the revision.